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Keilung Choy

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#machine learning Preprint Oct 2026

Adjoint-Based Calibration and Optimal Control of Stochastic Multiscale Bioprocess Digital Twins

We develop a bias-aware digital-twin calibration and control framework for multiscale bioprocess models within a biological systems-of-systems (Bio-SoS) paradigm. The digital twin is represented by a stochastic differential equation (SDE) model and calibrated from sparse, discrete observations using quasi-likelihood es...

Keilung Choy, Wei Xie · 0 citations

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