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Author

Keita Kajino

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Open access Oct 2026

Structure-signal relationships at κ-opioid receptor (KOR) revealed by bicyclo[2.2.2]octene enamide derivatives.

κ-Opioid receptor (KOR) agonists are promising candidates for analgesic development, yet their clinical application is limited by on-target adverse effects such as sedation and dysphoria. Attenuating β-arrestin2 recruitment while retaining G-protein signaling has therefore attracted interest as a strategy for improving...

Ruburika Nagao, Keita Kajino, Ryoji Kise et al. · 0 citations

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