Aug 2026
Polycation chain length determines the in vivo mRNA delivery efficiency of block copolymer micelles.
Tuning polycation chain length with core π-π interactions is key to unlocking highly efficient mRNA delivery in micelles, and achieves 2-fold higher protein expression in vivo compared to shorter or longer chain variants.
Yuki Nakashima, Pengwen Chen, Guanghao Hu et al.
· Biomaterials Science · 0 citations