Open access
Sep 2026
Cellular modifiers of TDP-43 phase transition and cytoplasmic aggregation
RNA-binding protein TAR DNA-binding protein 43 (TDP-43) can form liquid-like nuclear assemblies whose phase behavior is thought to influence its aggregation propensity and neurotoxic activity. The mechanisms that govern the liquid-to-solid phase transition of TDP-43 remain poorly defined. Here, we combined chemical and...
Natalie Chin, Qi Zhang, Ji-Zhong Zou et al.
· eLife · 0 citations