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Sponsored Artificial Intelligence: A Modern Approach, Global Edition Artificial Intelligence: A Modern Approach, Global Edition

Author

Ken Lee

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Open access Jul 2026

Pre-plaque glutamatergic hyperexcitability, mitochondrial dysfunction, and dendritic remodeling in the hippocampus of one-month-old 5xFAD mice

A pre-plaque window in 5xFAD mice marked by GluN2B-linked glutamatergic hyperexcitability, early mitochondrial disruption, and selective dendritic and transcriptional vulnerability is defined, suggesting that synaptic and metabolic dysfunctions arise before substantial plaque deposition and may represent tractable earl...

Amanda R. Kelley, Emily Sackinger, M. Frischman et al. · 0 citations

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