Ken R. Duffy

Rare Hematopoietic Stem Cells resilient to infection-induced stress sense yet withstand inflammation.

Hematopoietic stem cells (HSCs) sustain lifelong hematopoiesis as their progeny differentiate into all blood cell lineages. Homeostatic HSCs are mostly quiescent and only rarely divide, however their proliferation and differentiation rates can be modulated by external factors. Acute and chronic infections from a wide r...