Open access
2026
Whole-genome sequencing-based profiling of CYP2D6 structural variants in Japanese patients with solid tumors.
Cytochrome P450 2D6 (CYP2D6), a key enzyme involved in the metabolism of a wide range of pharmaceuticals, exhibits extensive genetic variants, including copy number variations (CNVs) and structural alterations. Hybrid alleles formed between CYP2D6 and its highly homologous pseudogene CYP2D7 frequently result in reduced...
Sumiko Ohnami, Takeshi Nagashima, K. Hatakeyama et al.
· Journal of Toxicological Sci... · 0 citations