When Homing Endonuclease Meets Transposon: The OMEGA System
Simple Summary The CRISPR-Cas9 and CRISPR-Cas12 systems recognize target DNA through base pairing with their guide RNAs, revolutionarily simplifying the design of DNA endonucleases with novel target-sequence specificity for genome editing and gene therapy, compared with endonucleases that rely on protein-based target r...