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Kenji Miyazawa

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Open access Jul 2026

Construction of a translational whole-body physiologically based pharmacokinetic model to investigate the biodistribution of lipid nanoparticle-based mRNA therapeutics for intracellular protein targets

This whole-body PBPK framework provides a mechanistic and predictive platform to support first-in-human dose selection, to interrogate multilevel determinants of mRNA pharmacokinetics, and to guide rational mRNA-LNP design.

Kenji Miyazawa, H. Bazzazi, Wei Gao · 0 citations

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