Open access
Jul 2026
Construction of a translational whole-body physiologically based pharmacokinetic model to investigate the biodistribution of lipid nanoparticle-based mRNA therapeutics for intracellular protein targets
This whole-body PBPK framework provides a mechanistic and predictive platform to support first-in-human dose selection, to interrogate multilevel determinants of mRNA pharmacokinetics, and to guide rational mRNA-LNP design.
Kenji Miyazawa, H. Bazzazi, Wei Gao
· Journal of Pharmacokinetics... · 0 citations