Author

Kenji Mizuguchi

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Open access Nov 2026

Identifying Short Half-Life Compounds from Structure Information Using Multi-Task Graph Neural Networks

Accurate prediction of terminal half-life (t1/2) is paramount for prioritizing drug candidates during the lead optimization stage, as it minimizes the risk of clinical trial failure while optimizing resource allocation. Drugs characterized by suboptimal t1/2 profileseither excessively short or prolongedpresent sign...

Ryoko Terada, Reiko Watanabe, H. Komura et al. · Molecular Pharmaceutics · 0 citations

Open access Sep 2026

Lysophospholipase PNPLA7 is a critical checkpoint of phosphatidylcholine catabolism and turnover for skeletal muscle homeostasis.

Current evidence suggests that disturbed phosphatidylcholine (PC) turnover causes skeletal muscle dysfunction. However, the enzyme that converts lysophosphatidylcholine (LPC) to glycerophosphocholine (GPC), an irreversible checkpoint in PC catabolism, in skeletal muscle has remained unidentified. Here we show that PNPL...

Shoya Matsumoto, Heeyoon Seo, Y. Taketomi et al. · Cell Reports · 0 citations