Author

Kenneth M. Humphries

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Open access Oct 2026

Mitochondrial oxidative stress in skeletal muscle alters metabolic signaling responses to acute muscle contraction.

Activation of redox-sensitive signal transduction cascades is an increasingly appreciated mechanism of exercise adaptation in skeletal muscle. Aging and disease are associated with altered redox homeostasis, potentially altering redox responses to muscle contraction, and adaptations to exercise. It is unclear how chron...

Ethan L. Ostrom, Aurora Mattson-Hughes, James McDonald et al. · Free Radical Biology & Medic... · 0 citations

Open access Sep 2026

PFKFB2 Gates a Relationship Between Cardiac Glycolytic Regulation and Electrophysiological Function.

BACKGROUND The cardiac isoform of PFKFB2 (phosphofructokinase-2/fructose 2,6-bisphosphatase) is the heart's strongest glycolytic regulator but is degraded in the absence of insulin signaling. This makes PFKFB2 loss critical to understand in metabolic heart disease, of which impaired insulin signaling is a hallmark. Pro...

Kylene M. Harold, Harris E. Blankenship, Keaton E. Minor et al. · Circulation: Arrhythmia and... · 0 citations

Open access Jul 2026

iPLA2β: A novel store-operated calcium entry modulator contributing to muscle dysfunction during denervation

iPLA2β deletion normalizes SOCE, preserves Ca2+ homeostasis, and protects against denervation-induced muscle mass and strength loss, revealing that iPLA2β may be a critical link between oxidative stress and Ca2+ dysregulation and a promising target for mitigating muscle dysfunction during denervation.

Hongyang Xu, S. Bhaskaran, Jacob L. Brown et al. · Science Advances · 0 citations