Akabane virus (AKAV) causes abortion, stillbirth, and congenital malformations in ruminants, yet the transcriptional response of Madin–Darby bovine kidney (MDBK) cells and the roles of infection-responsive host genes in AKAV replication remain incompletely characterized. We profiled AKAV-infected and time-matched mock-...
Xiang-Xiang Tan, Miao-Miao Zhang, Can-Yuan Li et al.· Veterinary Sciences· 0 citations
Foot-and-mouth disease (FMD) is a highly contagious viral disease affecting cloven-hoofed animals and poses severe economic losses to the sheep industry. In intensive sheep farming, simultaneous administration of the FMD vaccine with other vaccines or anthelmintics is frequently practiced to reduce handling stress and...
Sha-Sha Wang, Li-Mei Qin, Miao-Miao Zhang et al.· Frontiers in Cellular and In...· 0 citations
This study establishes a useful molecular foundation for understanding PRRSV-1 evolution in China and offers valuable insights for the development of broad-spectrum vaccines and effective control strategies.
Fang Liang, Tian-Yuan Nie, Pei-Xiu Lin et al.· Microorganisms· 0 citations
Overall, NSP1 was found to be under predominant purifying selection while retaining localized variability, lineage-biased residue patterns, and candidate recombination signals that should be interpreted cautiously and validated experimentally.
Tian-Yuan Nie, Jiaman Li, Si-Qi Ye et al.· Genes· 0 citations
The evolutionary and structural characteristics of the GP5 gene were analyzed to predict potential evolutionary patterns of PRRSV and provide molecular insights into prevention strategies and vaccine development.
