Sep 2026
Nociceptin orphanin F/Q Pathways are dysregulated by stress and modulate reward responsiveness and motivated behavior across species.
It is indicated that chronic stress alters Pnoc and mRNA levels of Pnoc-expressing cells in a sex-selective and region-specific manner impacting reward structures, and that NOPR antagonism shows promising efficacy in increasing reward-related behaviors in rodents and humans.
D. Pizzagalli, Meghan E. Gallo, M. Treadway et al.
· Molecular Psychiatry · 0 citations