Sep 2026
Abstract PR003: NF1 loss disrupts a SMARCA2–CTCF–H1 chromatin-remodelling axis and creates DNA repair vulnerability in retinoic acid–resistant high-risk neuroblastoma
Neuroblastoma (NB) is an aggressive childhood malignancy arising from the developing sympathetic nervous system. NF1 loss-of-function (LoF) and activating-RAS mutations both result in downstream activation of RAS-pathway signalling, are enriched at relapse, and associated with differentiation block. We show that fail...
Khushboo Agrawal, Z. Kozik, Matthew Shipley et al.
· Cancer Research · 0 citations