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Kevin J. Frankowski

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Open access Aug 2026

Discovery of Highly Potent G Protein-Biased Bisamide Kappa Opioid Receptor Agonists.

Kappa opioid receptor (KOR) agonists are used clinically to treat chronic itch and are promising candidates for the treatment of pain and other maladies. Unfortunately, adverse effects have hampered the widespread clinical development of KOR agonists. Preferentially stimulating the G protein activation pathway over the...

Kimberly S. Taylor, Kerri M. Czekner, Aubrie A. Harland et al. · 0 citations

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