Kevin M. Reynolds-Caicedo

Direct and Indirect Modulators of TDP-43 Aggregation in vitro

Amyotrophic lateral sclerosis is a devastating neurodegenerative disease that predominately affects upper, bulbar, and spinal motor neurons. Prognosis remains poor, with most patients succumbing to respiratory failure within five years of diagnosis. Although ALS has been clinically recognized and diagnosed for over 150...