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Author

Kevin M. Weeks

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Review Open access Sep 2026

mRNA Structure Regulates Translation at Every Step

Precise, context-sensitive control of protein synthesis is critical in eukaryotic cells, and mRNA structure has emerged as a central mechanism for achieving this control. mRNA structures influence every stage of translation. During initiation, structures within 5′ untranslated regions modulate ribosome association with...

Alexandra Khitun, Kevin M. Weeks · 0 citations
Open access Sep 2026

Large-scale structural analysis of pre-mRNA structure using RADIS

This work has developed RADIS (Reactivity Analysis of Deep and Intergenic RNA Structure), a strategy that yields strand-resolved chemical probing reactivity profiles across entire intron-rich loci by creating tiled arrays of RNAs that comprehensively span long genomic distances.

Claire Fleurisson, Si-Jin Chen, Ryan M. Macdonald et al. · 0 citations

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