APOBEC3 Knockout in Lentiviral Packaging Cells Improves Therapeutic Transgene Sequence Fidelity.
Lentiviral vectors are a well-established method of delivering transgenes into target cells. Lentiviral vectors have a strong efficacy and safety profile, but transgene fidelity remains an area of concern. Loss of function mutations within the integrated transgene may reduce therapeutic efficacy. Gain of function mutat...