Open access
Aug 2026
Nalbuphine and esketamine combination prevented postoperative hyperalgesia in patients undergoing laparoscopic cholecystectomy: a factorial design, double-blind, randomized controlled trial
Perioperative continuous infusion of remifentanil can lead to postoperative hyperalgesia. Nalbuphine and esketamine are adjunctive analgesics in general anesthesia. This study aimed to investigate the effect of the preoperative combined application of esketamine and nalbuphine on remifentanil-induced hyperalgesia i...
Yi Yang, Wenshan Zhai, Keyao Zhang et al.
· Scientific Reports · 0 citations