Author

Khaled S. Abd-Elrahman

2 papers indexed here

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Open access Aug 2026

TRIM9 Determines Sex-Specific β-Amyloid/Cellular Prion Protein/mGluR5 Complex Formation and Pathological Signaling in Alzheimer’s Disease Mice

Biological sex is a major determinant of Alzheimer’s disease prevalence, yet the molecular mechanisms underlying sex-specific vulnerability remain largely unknown. Metabotropic glutamate receptor 5 (mGluR5) functions as a co-receptor for β-amyloid (Aβ42) oligomer/cellular prion protein (PrPC)-mediated pathogenic signal...

Fatemeh Babaei, Fatemeh A. Panahi, Tash-Lynn L. Colson et al. · bioRxiv · 0 citations

Open access Aug 2026

Restoring neurovascular coupling in Alzheimer’s disease tauopathy through M1 mAChR modulation

Alzheimer’s disease is characterized by progressive cognitive decline and early cerebrovascular dysfunction, including impaired neurovascular coupling (NVC) and reduced cerebral blood flow (CBF). Tau pathology is a major driver of these deficits, yet therapeutic strategies targeting tau-induced neurovascular dysfunctio...

Wesam Bassiouni, Mohamed Abdelnaby, Enomoto Ai et al. · bioRxiv · 0 citations