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Khalil Khashei Varnamkhasti

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Review Open access Aug 2026

Therapeutic CRISPR/Cas9 delivery approaches: strengths, limitations, and a roadmap for clinical translation

A major focus of this review is the inclusion of recent hybrid systems (VLPs, SORT-LNPs) and the recognition that chemical modification of guide RNAs is a critical parameter for therapeutic success and that hybrid systems and stimuli-responsive nanoparticles are poised to dominate the next 5 years of clinical development.

M. Rezaee, F. Izadi, Saeed Nobaharian et al. · 0 citations