Review
Open access
Jul 2026
Host systemic metabolism and cancer metabolic vulnerabilities: mechanisms and therapeutic opportunities
Background Central molecular mediators—including hypoxia-inducible factors (HIF-1α/HIF-2α), MYC, wild-type and mutant p53, NF-κB, STAT3, SREBPs, NRF2, and KRAS—orchestrate these pathways by linking nutrient availability to oncogenic signalling, epigenetic reprogramming, and immune-metabolic crosstalk within the tumour...
Rashid Mir, J. Barnawi, Naseh A. Algehainy et al.
· Frontiers in Oncology · 0 citations