EPS8 dampens the growth dynamics and prolongs the lifetime of actin-based protrusions.
Actin-based membrane protrusions such as filopodia, microvilli, and stereocilia support a range of cell functions, from nutrient absorption to mechanosensation. In each case, membrane deformation is supported by a core bundle of actin filaments, organized in a unipolar 'barbed-end out' manner. Although their structures...