Untangling the effects of within-host and between-host natural selection in viruses with applications to evolution of HIV-1 co-receptor usage
A population-genetic model and software are developed for the inference of multi-level selection coefficients underlying HIV-1 ‘co-receptor switching’, estimating that the relative transmissibility of X4-tropic virus is 9%, while within-host switching to X4-tropism is approximately 7-fold higher than switching to R5-tr...