Kilian Klaus

Adenylation Domain Engineering Enables Biosynthesis of an Improved Polymyxin Antibiotic.

Polymyxins are potent nonribosomal peptide antibiotics, yet their clinical use is limited by a narrow therapeutic window and nephro-/neurotoxicity. Conventional efforts to improve these agents rely on the incorporation of nonnatural building blocks that cannot be accessed biosynthetically and therefore must be introduc...