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Sponsored Artificial Intelligence: A Modern Approach, Global Edition Artificial Intelligence: A Modern Approach, Global Edition

Author

Kimberly A. Foster

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2 papers indexed here

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Aug 2026

Discovery of BMS-986449: A Potent, Selective Degrader of the Transcription Factors IKZF2 (Helios) and IKZF4 (Eos) to Target Regulatory T Cells in Solid Tumors.

Within the tumor microenvironment (TME), regulatory T (Treg) cells promote an immunosuppressive state with limited tumor antigen presentation and antitumor effector T (Teff) cell responses, which can drive resistance to cancer immunotherapies. IKZF2 (Helios) is a transcription factor essential for stabilizing the immun...

E. Cherney, S. Nair, Suresh Babu Viswa Krishna Penmetsa et al. · 0 citations
Sep 2026

Mechanistic Insights into Drug Release from PLGA- and PLA-Based Implants

Biodegradable polymer implants offer long-acting drug delivery, yet the roles of polymer chemistry and drug properties in governing release remain incompletely understood. We hypothesized that polymer viscosity and end-group chemistry regulate water uptake, glass-transition, and chain mobility, thereby controlling im...

Dong-Yue Yu, Ryan V. Schroder, Arnold Teo et al. · 0 citations

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