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Kirstyn Loyva

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Open access Oct 2026

Methylation-associated Gene Expression (MaGE): a non-invasive, in vivo measure of cellular senescence

Cellular senescence is a central hallmark of aging, yet its measurement in humans remains invasive, low-throughput and tissue-specific, precluding population-scale study. We developed Methylation-associated Gene Expression (MaGE) predictors: whole-blood DNA methylation proxies of p14ARF, p16INK4A and p21CIP1 expression...

Daniel J. Simpson, S. Crofts, Christos Mavrommatis et al. · 0 citations

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