Exploiting the rubbery-state transition of PLGC nanoparticles for enhanced intracellular paclitaxel delivery and anti-tumor efficacy.
The therapeutic efficacy of polymeric nanocarriers is often restricted by rigid, glassy matrices that hinder drug diffusion and poorly controlled surface interactions that limit cellular uptake. This study exploits the temperature-induced, rubbery-state transition of poly(lactide-co-glycolide-co-caprolactone) (PLGC) na...