Kiyoshi Yamaguchi

BRD8 deficiency leads to progressive impairment of spermatogenesis in mice.

BRD8, a member of the bromodomain-containing protein family, is a chromatin-associated protein that recognizes acetylated histones and recruits regulatory factors to modulate gene expression. Despite extensive studies of BRD8 in tumor biology, its physiological roles in normal tissues remain largely unknown. Given its...