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Author

Klára Šabatková

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Open access Sep 2026

Metformin-mediated immunometabolic rewiring attenuates type I interferon-driven dendritic cell inflammation in STAT1 gain-of-function

Gain-of-function (GOF) mutations in STAT1 are associated with immune dysregulation, impaired antifungal immunity and features of chronic type I interferon pathway activation. Here, we investigated whether metformin, a widely used metabolic modulator, can attenuate inflammatory dendritic cell activation in STAT1 GOF....

Z. Parackova, Klára Šabatková, M. Kolarik et al. · 0 citations

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