Author

Koichi Watashi

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Open access Sep 2026

Phage genomes are enriched with genes to overcome diverse bacterial immune systems

Phages and bacteria are engaged in an evolutionary arms race, where phages continually evolve new strategies to overcome bacterial defenses. To systematically investigate the functions of all genes within phage genomes, we constructed a gene deletion library of the Escherichia coli phage phiDruSM1, belonging to t...

Shinjiro Ojima, A. Azam, Kohei Kondo et al. · Communications Biology · 0 citations

Open access Aug 2026

RNase-mediated defence and its association with SCCmec in Staphylococcus aureus

The rise of antibiotic resistance in Staphylococcus aureus is a major threat to global health. Resistance often emerges when bacteria acquire foreign DNA elements, such as the SCCmec cassette that makes strains resistant to nearly all β-lactam antibiotics. Yet, not all S. aureus lineages take up these elements equally,...

Kohei Kondo, A. Azam, J. Hisatsune et al. · Nature Communications · 0 citations

Open access Aug 2026

A viral-vectored multipathogen vaccine platform based on replication-competent vaccinia virus and adeno-associated virus

The feasibility of the m8Δ/AAV1 platform is demonstrated as a versatile viral-vectored multipathogen vaccine platform capable of integrating protozoan and viral antigens, providing a rationale for further preclinical optimization and clinical evaluation of next generation multipathogen vaccines targeting both endemic a...

Yuna Sato, Yutaro Yamamoto, A. Hasyim et al. · Frontiers in Immunology · 0 citations