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Open access Aug 2026

Multifaceted renoprotection by SMTP-44D in diabetic nephropathy: Targeting inflammation, oxidative stress, and insulin resistance.

Diabetic nephropathy (DN) is a major complication of diabetes and a leading cause of dialysis initiation. However, treatment options for DN are currently limited, highlighting the urgent need for novel therapies. The pathogenesis of DN involves persistent chronic hyperglycemia and advanced glycation end products, leadi...

Taiki Awane, K. Shibata, Daisuke Saigusa et al. · 0 citations
Open access Sep 2026

SMTP-44D Attenuates Renal Inflammatory/Oxidative Dysfunction in a Mouse Model of Ischemia–Reperfusion-Induced Acute Kidney Injury

Acute kidney injury (AKI) is a critical clinical challenge for which effective pharmacological therapies remain limited. Inflammation and oxidative stress play central roles in its pathogenesis. Here, we investigated the effects of Stachybotrys microspora triprenyl phenol-44D (SMTP-44D), a soluble epoxide hydrolase inh...

K. Shibata, Keiji Hasumi, Koji Nobe · 0 citations

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