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Author

Koji Oba

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Open access Oct 2026

Topology-adjusted knockout (TAKO): interpretable in silico single-gene knockout ranking on wild-type single-cell gene regulatory networks

Predicting single-gene knockout effects from wild-type single-cell RNA-seq data remains challenging when perturbation experiments are costly and existing approaches require knockout-specific model training. Here we introduce Topology-Adjusted Knockout (TAKO), a computationally efficient WT-only framework for single...

Hao Wang, Koji Oba · 0 citations
Review Open access Aug 2026

Recommendations for generating real-world evidence with regulatory-grade relevance and reliability

A purpose-oriented framework clarifying the levels of relevance and reliability required according to specific regulatory objectives is proposed, and practical recommendations for generating regulatory-grade RWE that meaningfully informs regulatory decision-making while complementing conventional clinical trials are pr...

Yasutoshi Sakamoto, H. Bando, Yoshihiro Aoyagi et al. · 0 citations

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