Konstantinos D. Tsirigos

DeepTMHMM2 enables accurate prediction of transmembrane protein topology and subcellular location

Transmembrane α-helical and β-barrel proteins are a ubiquitous component of proteomes. Topology prediction infers how proteins are embedded in lipid bilayers, identifying membrane-spanning segments and their orientation. While recent methods achieve high performance for membrane-spanning segments, they cannot predict r...