Author

Krishan Walpalage

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Open access Aug 2026

Probing Mechanisms of Allosteric Regulation in AAA+ ATPases for Microtubule Severing and Protein Disaggregation

It is found that both nucleotide and substrate polypeptide binding restrict the conformational landscape sampled by katanin and ClpB, with ligand-specific conformations observed in the latter case.

Maryum Irshad, Krishan Walpalage, Zhaocheng Zhang et al. · bioRxiv · 0 citations