Author

Kristen M. Naegle

3 papers indexed here

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Sep 2026

Abstract PR012: Encoding adaptive mechanisms of resistance to KRAS inhibition in pancreatic cancer

Clinical outcomes for pancreatic ductal adenocarcinoma (PDAC) remain poor. Although ∼90% of PDAC tumors harbor oncogenic KRAS mutations and KRAS inhibitors (KRASi) have shown clinical promise, adaptive resistance limits response depth and durability. While EGFR-mediated RAS-MAPK pathway reactivation has been impl...

Qing-Xiang Lin, Bo-Kai Song, C. Sander et al. · Cancer Research · 0 citations

Open access Aug 2026

Studying the effect of conserved tyrosine phosphorylation within SH2 domains

SH2 domains are phosphotyrosine-binding modules that play a critical role in cell signaling by mediating protein-protein interactions. While tyrosine phosphorylation has been shown to impact SH2 domain function in signaling, the specific effects of phosphorylation at different sites within the domain remain poorly unde...

Gabrielle Martinez, Mindolay Fike, Madhuri Sosale et al. · bioRxiv · 0 citations

Open access Aug 2026

SpY-C: Supervised Learning of Phosphopeptide Sequence Constraints Enables Global Prediction of SH2 Domain Binding

Tyrosine kinase signaling for cell development and homeostasis in multicelluar organisms and a major biochemical contribution is by driving interactions between phosphorylated tyrosines (pY) and SH2 domain containing proteins. This assembly is so important to driving cell outcomes that a wide variety of experimental an...

Alekhya Kandoor, A. C. Silva Oliveira, K. Machida et al. · bioRxiv · 0 citations