These findings extend the bradykinin hypothesis of ACEI-induced cough by implicating neurotensin-NTSR1 signalling, pinpoint CYP3A4*22 as a novel functional predictor of dCCB switching with potential for genotype-guided prescribing, and validate medication use trajectories as a framework for pharmacogenetic discovery.
F. Vaura, Kristi Krebs, T. Kiiskinen et al.· European Heart Journal· 0 citations
A genomic meta-analysis of case–control studies of binge-eating behavior and analyses of anorexia nervosa and its subtypes, alongside analyses of AN, identified six BE-associated loci and eight areas that are associated with anorexia nervosa, in people of European ancestry.
Jet D. Termorshuizen, Helena L. Davies, Sang-Hyuck Lee et al.· Nature Mental Health· 1 citation
BPD showed the strongest positive genetic correlations with GWAS of post-traumatic stress disorder, depression, attention deficit hyperactivity disorder, antisocial behavior, antisocial behavior, and measures of suicide and self-harm.
F. Streit, S. Awasthi, Alisha S. M. Hall et al.· Nature Genetics· 1 citation
This work developed a neural network model, nnCNV, to predict deletions in the CYP2C19 pharmacogene region from array intensity signals and demonstrated that long-range information, which cannot be utilized by hidden Markov models, can improve CNV calling.
Burak Yelmen, R. Hofmeister, Viido Kaur Lutsar et al.· bioRxiv· 0 citations
We use cookies to run the site and, with your consent, for analytics and to show ads.
See our Cookie Policy.
