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Author

Kristin B. Artinger

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3 papers indexed here

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Open access Oct 2026

PRDM16 is necessary for sensory neuronal development and differentiation in the trigeminal ganglion.

BACKGROUND Cranial neural crest cells (cNCC) generate craniofacial cartilage, bone, and peripheral neurons and glia, and birth defects arise when the cartilage/neuronal/glial progenitors fail to differentiate. PRDM16 is a transcriptional regulator containing both zinc-finger and SET domains, implicated in craniofacial...

Fahmida Raha, Qi-Man Gao, L. Shull et al. · 0 citations
Open access Sep 2026

Synergistic targeting of EP300/CBP and EYA co-activators collapses the rhabdomyosarcoma core regulatory circuit

A novel approach to target RMS transcription comprising simultaneous targeting of two distinctly acting transcriptional co-activators dually targets CRC-associated co-activators to cooperatively suppress the RMS transcriptome and enforce cell death.

Alrik Gustafson, S. Nance, B. Gryder et al. · 0 citations
Sep 2026

Abstract B005: Synergistic targeting of EP300/CBP and EYA co-activators collapses the rhabdomyosarcoma core regulatory circuit

Rhabdomyosarcoma (RMS) is a high-risk pediatric sarcoma that resembles developing skeletal muscle. Transcriptional dysregulation drives RMS pathogenesis in tumors carrying chimeric transcription factors (“fusion-positive (FP)”), and those without (“fusion-negative” (FN)). Here, we develop a novel approach against RMS...

Brian J. Abraham, Annika L. Gustafson, S. Nance et al. · 0 citations

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