Review
Open access
Sep 2026
Ubiquitin-Dependent Protein Quality Control in Polyglutamine Diseases.
Polyglutamine diseases comprise a family of nine age-dependent disorders caused by CAG triplet-repeat expansions that produce misfolded proteins with elongated glutamine tracts. Although these diseases share proteotoxic stress and engagement of protein quality control pathways as responses to their presence and disrupt...
Matthew V. Prifti, Kristin Richardson, Sokol V. Todi
· Aging and Disease · 0 citations