NTRODUCTION: Alzheimer's disease (AD) shows sex differences in risk, clinical progression, and biomarker profiles, but whether inherited genetic liability to modifiable risk factors contributes differently to AD susceptibility in females and males remains unclear. We evaluated whether genetic relationships between seve...
R. Sharma, P. Tolosa-Tort, M. Okorie et al.· medRxiv· 0 citations
BACKGROUND
Despite increasing incidence of stroke among younger adults, the associations of social determinants of health (SDOH) and stroke among younger adults are not well known. This study investigates the associations between SDOH from early adulthood and stroke in a prospective longitudinal cohort.
METHODS
We st...
Nathaniel H. Fleming, C. Dintica, Alexander Arynchyn et al.· Stroke· 0 citations
Dementia clinical risk scores (CRSs) provide accessible tools for identifying individuals at risk for Alzheimer's disease (AD) and related dementias, yet their performance across diverse populations and relationships to AD endophenotypes remains unclear.
M. Okorie, Xia-Qing Jiang, K. Yaffe et al.· Alzheimer's & Dementia· 0 citations
Middle-aged adults with faster 15-year epigenetic aging trajectories demonstrated worse cognitive performance, whereas those with slower biological aging trajectories exhibited cognitive resilience and more favorable AD biomarker profiles.
Ana I. Boeriu, Shea J. Andrews, T. Hoang et al.· medRxiv· 0 citations
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