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Kuan Pang

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#artificial intelligence Preprint Nov 2026

ProteoCraft: Protein Design as Proposal-Verification Search

Protein-protein interactions underpin nearly all biological processes. Yet, designing proteins with desired interactions remains challenging due to the structural complexity governing molecular recognition. This study views protein design as a search optimization problem over a combinatorial sequence space under expens...

Fang Wu, Hong-Bin Lin, Bing-Chen Duan et al. · 0 citations
Open access Aug 2026

Perturb-ME: Scalable mechanism discovery from phenotype-enriched genome-wide screens

Perturb-ME, along with agentic interpretation, provide a scalable framework for comprehensive functional discovery from phenotype-enriched genetic screens and combines genome-scale CRISPR screening, phenotype-based enrichment and multimodal single-cell profiling.

Han-Chen Wang, Jiacheng Gu, Chris J. Frangieh et al. · 0 citations

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