Importazole suppresses proliferation and modulates KPNB1 and Bax/Bcl-2 expression in HepG2 hepatocellular carcinoma cells: bioinformatic, in vitro, and in ovo analyses
Background: Hepatocellular carcinoma (HCC) is a major cause of cancer-related mortality and is associated with limited therapeutic options and poor prognosis at advanced stages. Although aberrant activation of importin-β-dependent nuclear transport has been reported in several malignancies, the clinical and therapeutic...