Kun-Che Peng

Transient Calcium Signaling Reprograms YAP Mechanosensitivity through Actin Remodeling.

YAP is a central regulator of cell fate, proliferation, and tissue homeostasis that integrates physical cues from the extracellular matrix (ECM). While stiff environments canonically drive YAP nuclear localization and soft environments promote cytoplasmic sequestration, the logic by which cells integrate mechanical inp...