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Author

Kun Liu

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Jul 2026

USP22 orchestrates an NK-suppressive program for tumor immune evasion 2309931

This study identifies USP22 as a tumor-intrinsic suppressor of NK- and CD8+ T-cell—mediated antitumor immunity and reports a USP22-specific inhibitor with dual onco-targeting and immune-boosting activity, representing a first-in-class therapeutic strategy.

De-Yu Fang, Kun Liu · 0 citations
Open access Jul 2026

Identification of a FoxP3-specific small molecule degrader with potent antitumor immunotherapeutic efficacy 2309510

The first FoxP3-specific small molecule degrader which promotes proteasomal degradation of FoxP3 and partially reduces Treg suppressive function is reported, demonstrating proof-of-concept and feasibility of targeting FoxP3, which has been known to be “undruggable”, in a chemical manner by small molecules.

Amy Y. Tang, Zhao-Meng Cai, Kun Liu et al. · 0 citations

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