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Open access Sep 2026

Plasma metabolic fingerprinting identifies phenylalanine as a mortality biomarker in elderly ARDS patients

Currently, there remains a lack of effective prognostic biomarkers specifically for ARDS patients. We conducted a retrospective study profiling plasma metabolomics (ARDS = 55, non-ARDS = 37) via high-throughput NPELDI-MS. Machine learning (LR, SVM, NN) developed age-stratified prognostic models (< 65 vs. ≥...

Yan-Yan Li, Jing Xu, Bo-Shun Zhang et al. · 0 citations
Open access Oct 2026

Metabolic Signatures for Liver Cancer Diagnosis and Mechanistic Insights: A Large‐Scale, Multicenter Study

ABSTRACT The poor prognosis of liver cancer (LC) highlights the urgent need for more effective strategies for early detection. We conducted a large, multicenter study to develop and validate a serum metabolic signature for LC diagnosis. Using high‐throughput nanoparticle‐enhanced laser desorption/ionization mass spectr...

Yong-Jie Xu, Jia-Chen Wang, Chun-Meng Ding et al. · 0 citations

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