Author

Kun Wang

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Open access Sep 2026

DNMT1 is associated with QDPR downregulation and chemotherapy response in lung adenocarcinoma

In lung adenocarcinoma (LUAD), DNA methylation-mediated gene silencing may contribute to tumor initiation, progression, and heterogeneity in treatment response. However, the key methyltransferases involved and their therapeutic potential have not been systematically characterized. This study aimed to address three majo...

Lyubo Wang, Gui-Cai Liang, Lei Zhu et al. · Medical Oncology · 0 citations

Aug 2026

Integrative multi-omics analysis identifies an enhancer-driven ELF3-CLDN4 regulatory axis that shapes an immunosuppressive microenvironment and predicts prognosis in high-grade serous ovarian cancer.

OBJECTIVES High-grade serous ovarian cancer (HGSOC) is marked by genomic instability, immune suppression, and poor outcome, yet enhancer-gene networks coordinating malignant epithelial programs and CD4⁺ T-cell states remain unclear. We aimed to identify enhancer-associated regulatory circuits linking tumor plasticity,...

Ping-Ping Xu, Kun Wang, Su-Yan Shen et al. · Gene · 0 citations