Open access
Sep 2026
Integrative transcriptomic analysis reveals KLHL2 downregulation as a potential driver of microglial inflammation in Alzheimer’s disease via the WNK3/JNK/c-Jun axis
Alzheimer’s disease (AD) is a progressive neurodegenerative disorder characterized by prominent neuroinflammation. Microglia, the resident immune cells of the central nervous system, play a key role in AD-associated neuroinflammation, yet the molecular mechanisms regulating their inflammatory activation remain incomple...
Yao Yang, Cong-Hui Dai, Zong-Tang Xu et al.
· Neurotherapeutics · 0 citations