Author

Kun-Yu Lu

2 papers indexed here

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Open access Oct 2026

GTPase GBP7 promotes HSV-1 infection by interacting with and activating eEF1A1 to accelerate the protein translation process.

Guanylate-binding proteins (GBPs) are immune GTPases induced by interferons (IFNs) and comprise GBPs1-7. In this study, GBP7, a less studied member of the GBPs, was identified to possess Herpes simplex virus I (HSV-1) promoting effects on replication both in vitro and in vivo. Knockdown of GBP7 or loss of its GTPase ac...

Jin-Shen Wang, Liang-Bing Man, Bin-Hao Rong et al. · PLoS Pathogens · 0 citations

Aug 2026

Structure-Based Design and Optimization of Onradivir-Derived PB2 Inhibitors for the Treatment of Influenza A.

Influenza A remains a major seasonal public health burden. With the approval of onradivir, PB2 has emerged as an attractive antiviral target due to its unique and conserved structural features. Herein, using onradivir as the lead, we employed bioisosteric replacement strategies to design a series of derivatives for SAR...

Yujian Yang, Bin-Hao Rong, Xing-Yu Zhou et al. · Journal of Medicinal Chemist... · 0 citations