Kunihiko Kaneko

Global geometry of the genotype-phenotype map illuminates a trade-off between penetrance and mutational adaptability

An abstract model of stochastic genotype-phenotype mapping, inspired by interacting spins in statistical physics, permits exhaustive reconstruction of the map and finds that high-penetrance genotypes tend to occupy the interior of environment-specific high-fitness regions and are mutationally robust, whereas lower-pene...