Kuo-Cheng Lu

Calcimimetics and CaSR signaling in CKD-MBD: bone–immune–vascular crosstalk and therapeutic potential

Chronic kidney disease (CKD) disrupts mineral metabolism, skeletal remodeling, vascular homeostasis, and immune regulation, producing the systemic phenotype of CKD-mineral and bone disorder (CKD-MBD) together with chronic inflammation and impaired host defense. Osteoimmunology provides a framework for understanding how...